Pathogenesis of t(8;21) acute myeloid leukemia and the progress of next generation sequencing technique in leukemia

Acute myeloid leukemia (AML), the most common disease in acute leukemia, is a highly heterogeneous invasive hematological disease. The t(8;21)(q22;q22) translocation is the most common chromosomal translocation in AML, generating AML1-ETO fusion gene and encoding AML1-ETO fusion protein. This article summarizes the "two-hit" hypothesis in AML occurrence, the pathogenesis of t(8;21)AML, all features involved in t(8;21)AML, and the function of the components in AML1-ETO fusion protein, providing important basic information for the treatment and prognosis of t(8;21)AML. Meanwhile, this article also summarizes the progress of next generation sequencing technique in leukemia, providing a new technique for the accurate therapy of (8;21)AML. DOI: 10.11855/j.issn.0577-7402.2017.05.20