Multiple primary malignant neoplasms associated with genitourinary cancer

Abstract Between October 1980 and December 1994, we treated 392 patients with malignant neoplasms associated with genitourinary organs. We made a statistical study on 42 patients (10.6%) with multiple malignant neoplasms. The average age of 42 patients was 72.2 years and 83% of the patients were male. Malignant neoplasms originating from bladder, prostate or kidney were observed in 19 cases (35%), 19 cases (35%) or 10 cases (11%), respectively. The incidence of prostatic cancer was higher than that in other single primary malignant neoplasms associated with genitourinary organs. The other organs having malignant neoplasms accompanying genitourinary organs were the stomach (39%), lungs (12%), esophagus (9%), and pancreas (9%). Only 16 patients (35%) had synchronous multiple malignant neoplasms. However, 35 cases (75%) including these cases had second primary malignant neoplasms within 5 years of the first. In conclusion, the incidence of multiple malignant neoplasms with genitourinary cancer was as high as 10.6% and the prognosis of these patients was poor. These findings suggest the necessity of careful follow-up on patients with genitourinary cancer.