AB0295 Risk factors for progression and prognosis of rheumatoid arthritis-associated interstitial lung disease: single centre study with a large sample of chinese population

Background Poor prognosis has been shown in rheumatoid arthritis-associated interstitial lung disease (RA-ILD) patients, and the mortality rate was significantly higher than RA patients without ILD. Studies showed that one-third of RA-ILD patients had progressed within two years. However, factors associated with ILD progression and survival in RA-ILD have not been previously described in a large centre China cohort. Objectives To investigate the risk factors for ILD progression and explore the prognostic factors for survival in RA-ILD patients. Methods 791 consecutive RA patients who completed lung HRCT were considered as potential participates. 266 RA-ILD patients were finally included in this retrospective cohort study. To identify independent risk factors for ILD progression, multivariate logistic regression analyses were used. Cox hazards analysis was used to determine significant variables associated with survival. Results 1, The mean age at diagnosis of RA-ILD was 64.80±10.71 years old. 162 (60.90%) were females and 104 (39.09%) were males. 2, UIP and NSIP pattern were the commonly types of RA-ILD, accounting for 37.22% and 25.94% respectively. Extent of lung involvement analysis showed that limited was predominant (130/266, 48.87%), with smaller numbers of moderate (67/266, 25.19%) and extensive (69/266, 25.94%) lung involvement. 3, The 3 year survival rate of RA-ILD patients was 81.24%, and the 5 year survival rate was 69.71%. A total of 82 deaths occurred during follow-up, of which 56 died of respiratory failure due to ILD progression and/or pneumonia, while 14 with malignancies (8 with lung cancer). 4, Logistic regression analysis showed that an increased anti-CCP antibody titer (OR: 4.03, 95% CI: 1.04–15.69, p 60 years old) of RA-ILD diagnosis (HR: 2.32, 95% CI: 1.27–4.25, p Conclusions In RA-ILD patients, DLCO% References [1] Dawson JK, Fewins HE, Desmond J, Lynch MP, Graham DR. Predictors of progression of HRCT diagnosed fibrosing alveolitis in patients with rheumatoid arthritis. Ann. Rheum. Dis. 2002;61(6):517–521. [2] Koduri G, Norton S, Young A, et al. Interstitial lung disease has a poor prognosis in rheumatoid arthritis: results from an inception cohort. Rheumatology (Oxford)2010;49(8):1483–1489. [3] Hyldgaard C, Hilberg O, Pedersen AB, et al. A population-based cohort study of rheumatoid arthritis-associated interstitial lung disease: comorbidity and mortality. Ann. Rheum. Dis. 2017;76(10):1700–1706. Disclosure of Interest None declared