Ferrokinetic studies on normal and fluke-infected rabbits.
1970
Abstract The disappearance of radioiron from the plasma and its subsequent incorporation into red cells was studied in normal and fluke-infected rabbits. The results of these experiments show that erythropoiesis, as measured by the rate of removal of radioiron from the plasma and its subsequent incorporation into red cells, is greatly increased in fluke-infected relative to normal animals. As with 51 Cr-labelled red cells, a considerably shortened half-life of red cells labelled with 59 Fe occurs in infected animals, this being associated with an increased faecal excretion of the isotope, and hence of haemoglobin iron. The ability of the rabbit to re-utilise iron passed into the gut was estimated from the faecal excretion of 51 Cr and 59 Fe after simultaneously tagging the erythrocytes with these isotopes. It was found that both normal and infected animals were unable to re-utilise such iron. This was confirmed by following the faecal excretion of an oral dose of lysed red cells labelled with 51 Cr and 59 Fe.
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