Effects of Opiate Dependence Through Different Administration Routes on Pulmonary Inflammation and its Severity

Results: Severe perivascular inflammation was detected in 33.3% of the samples with oral opiate dependence and 20% of the cases addicted to opiate through inhalation. Also, severe peribronchial inflammation was observed in only 20% of the samples addicted to inhaled opiate and was not found in the other groups. No significant differences were found in the severity of perivascular and peribronchial inflammation across the three groups. Although the mean of total inflammation scale in the subjects with oral opiate dependence (3.00±1.79) was numerically higher than that in the inhaled dependence group (1.40±2.60) and the controls (2.25±1.26), this difference was not statistically significant. Conclusions: Administration did not influence the appearance or severity of pulmonary inflammation in animal models addicted to opiate.