LC-MS-based metabolomics analysis to identify meprin β-associated changes in kidney tissue from mice with STZ-induced type 1 diabetes and diabetic kidney injury

Jessica Renee Gooding,Lei Cao,Faihaa Ahmed,Jean-Marie Mwiza,Mizpha Fernander,Courtney Whitaker,Zach Acuff,Susan McRitchie,Susan Sumner,Elimelda Moige Ongeri

LC-MS-based metabolomics analysis to identify meprin β-associated changes in kidney tissue from mice with STZ-induced type 1 diabetes and diabetic kidney injury

2019

Jessica Renee Gooding
Lei Cao
Faihaa Ahmed
Jean-Marie Mwiza
Mizpha Fernander
Courtney Whitaker
Zach Acuff
Susan McRitchie
Susan Sumner
Elimelda Moige Ongeri

Meprin metalloproteases have been implicated in the pathophysiology of diabetic kidney disease (DKD). SNPs in the meprin β gene associated with DKD in the Pima Indians, a Native American ethnic gro...

Keywords:

Metalloproteinase
Type 1 diabetes
Internal medicine
Diabetes mellitus
Pathophysiology
Metabolomics
Single-nucleotide polymorphism
Endocrinology
Biology
Biochemistry
Kidney disease
Kidney
Kidney metabolism
Experimental pathology
Streptozotocin

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