Efficacy of Acotiamide (Z-338) in Patients With Postprandial Distress Syndrome or Overlap of Epigastric Pain Syndrome and Postprandial Distress Syndrome in Functional Dyspepsia

a table below. COV of % retention at 2h and 4h was much higher than COV of % of emptying at the same time both in H and GP. COVs of T50 and T90 were similar in H and GP. COV of GET was lower than COV of most GES parameters, being most close to T90 in H and GP. COV of GES reported as % of retained radioactive were extremely high, especially % retention at 4 hours. COV of GES % emptied were much lower despite the fact that the results express the same physiological event and are being calculated from the same data. Conclusions: Of all measurements, the COV of GET and T90 were most similar probably due to the close physiologic relationship between the events. Comparing WMC to GES results is best between T90 and GET. The COVs of 2 and 4 hour GES parameters can be skewed widely due to the bound nature of these later two parameters and the ceiling effect observed in the distribution of their normal data. Care must be taken when evaluating and comparing the performance characteristics of these tests results because the method of result reporting can dramatically affect the performance characteristics. Table 1. Coefficient of Variance of Gastric Emptying Results by GES and WMC in Healthy and Gastroparetics