Synthesis and Antiviral Activities of 1,3-Oxathiolanyl Nucleosides with 5-Hydroxymethyl Substituent

Moon Woo Chun,Sung Pil Choi,Myong Jung Kim,Chol Joon Bae,Hyung Ryong Moon,Hee-Doo Kim,Lak Shin Jeong

Synthesis and Antiviral Activities of 1,3-Oxathiolanyl Nucleosides with 5-Hydroxymethyl Substituent

2010

Moon Woo Chun
Sung Pil Choi
Myong Jung Kim
Chol Joon Bae
Hyung Ryong Moon
Hee-Doo Kim
Lak Shin Jeong

Abstract Novel 1,3-oxathiolanyl pyrimidine nucleosides with 5-hydroxymethyl substituent were synthesized starting from d-mannose and evaluated for antiviral activities against HIV-1, HSV type 1,2 and HCMV.

Keywords:

Hydroxymethyl
Nucleic acid
Substituent
Chemistry
Organic chemistry

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