The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β 1−40 peptide

Genome-wide association studies have established a link between the extracellular chaperone clusterin and susceptibility to Alzheimer's disease. A fluorescence approach is now used to reveal that clusterin sequesters Aβ1–40 oligomers and prevents them from undergoing further aggregation.