Nickel-catalyzed decarboxylative coupling of an alkynyl carboxylic acid with aryl iodides

Abstract A decarboxylative coupling reaction with an alkynyl carboxylic acid and aryl iodides in the presence of a nickel catalyst was developed. When the reaction was conducted with NiCl 2 (10 mol%), Xantphos (15 mol%), Mn (1.0 equiv), and Cs 2 CO 3 (1.5 equiv), the desired diaryl alkynes were formed in moderated to good yields. Furthermore, this method does not produce the diyne, which is formed in the homocoupling of alkynyl carboxylic acids.