Fosfomycin tromethamine one kind of preparation

The present invention provides a method for preparing fosfomycin tromethamine, comprising the steps of: (1) Preparation of p-toluenesulfonic acid tromethamine salt: p-toluenesulfonic acid monohydrate and an anhydrous alcohol in the solution A tromethamine reaction, then separated and dried to obtain water-free crystals of p-toluenesulfonic acid tromethamine salt; (2) preparation fosfomycin trometamol crude: p-toluenesulfonic acid in anhydrous tromethamine salt alcohol solution B with the left and right phosphate amine salt monohydrate fosfomycin trometamol reaction crude product; (3) purified fosfomycin trometamol: fosfomycin trometamol in an anhydrous alcohol solution of crude C in refined fosfomycin trometamol. Fosfomycin trometamol with a higher purity, a single crystalline form, the stability of the product obtained by the production method of the present invention is greatly improved.