Landscape of genomic alterations in cervical carcinomas

To provide an overview of the genomic aberrations that contribute to cervical cancer these authors performed whole-exome sequencing and analysis of 115 cervical cancernormal pairs, transcriptome sequences of 79 cervical carcinomas and whole-genomes from 14 cervical cancernormal pairs. Analyses identify MAPK1, HLA-B and ELF3 as novel significantly mutated genes and provide evidence that human papilloma virus integration is a common mechanism for target gene overexpression in cervical cancer. The results also provide a comparison of the mutational landscapes of squamous cell carcinomas and adenocarcinomas.