Synergism of cannabichromene and CNS depressants in mice

Abstract 1. 1. One intraperitoneal dose of the cannabinoid, cannabichromene (CBC), increased the duration of loss of righting reflex in mice after hexobarbital, barbital or zoxazolamine. 2. 2. After 7 daily doses of CBC, prolongation of response to the 3 drugs no longer occurred; duration for hexobarbital and zoxazolamine was less than for vehicle controls. 3. 3. The data reflect a CNS depressant action of CBC, the development of tolerance to this action, and a possible induction of drug metabolism.