В каких ситуациях показана комбинированная терапия гидроксихлорохином и лопинавиром/ритонавиром, и как следует осуществлять контроль безопасности терапии?

Some guidelines describe combined use of hydroxychloroquine and lopinavir/ritonavir as one of the treatment alternatives for severe COVID-19, yet this treatment is not preferable. It requires careful consideration of possible interactions with other drugs, monitoring of cardiotoxicity (including QT-interval measurement), and hepatotoxicity (measurement of ASAT/ ALAT).