CARDIAC NATRIURETIC PEPTIDE DEFICIENCY PREDISPOSES TO ARRHYTHMIAS AND SUDDEN DEATH FOLLOWING ACUTE CARDIAC STRESS

The cardiac natriuretic peptides, atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP), play an important role in regulating cardiovascular physiology. These peptides bind the natriuretic peptide receptors with similar affinities, yet ANP- and BNP-deficient mice are reported to have