Identificación del perfil de metaloproteasas de matriz extracelular en membranas corioamnióticas de embarazos a término y pretérmino mediante microarreglos solubles

Background: Physiological and pathological membrane rupture is a complex phenomenon with different biochemical processes; it is known that collagenolitic activity rises and collagen content diminishes within term tissue membranes in comparison to preterm membranes. Identification of these processes within rupture mechanism allows to suggest that fetal membranes and decidua can respond to biochemical and mechanical stimulus alike, and to produce mediators that degrade matrix of intracellular membranes. Objective: To identify simultaneously, whit a soluble microarray, different matrix metalloproteinases in extracts from amniochorion of