Prognostic value of tricuspid annular plane systolic excursion and right ventricular outflow tract fractional shortening in mechanically ventilated septic patients

Abstract Objective : We aimed to explore whether tricuspid annular plane systolic excursion (TAPSE) and right ventricular outflow fractional shortening (RVOT-FS) were associated with long-term prognosis in mechanically ventilated septic patients. Design : A prospective observational study. Setting : A tertiary hospital intensive care unit (ICU). Participants : One hundred eighty-one septic patients who were on mechanical ventilation. Interventions : Echocardiography were performed within 24 hours of ICU admission. Measurements and Main results : Several echocardiographic parameters, including TAPSE and RVOT-FS, as well as prognostic information were collected. A Cox regression survival analysis showed that TAPSE was independently associated with one-year all-cause mortality (HR 0.407, 95% CI:0.200-0.827, p=0.013), but ROVT-FS was not (HR 0.997, 95% CI:0.970-1.025, p=0.828). ROC analysis showed that the optimal cutoff value for TAPSE and RVOT-FS to determine one-year mortality were TAPSE Conclusions : TAPSE was an independent predictor of one-year all-cause mortality in mechanically ventilated septic patients. RVOT-FS was not associated with one-year mortality and added no prognostic value to TAPSE in these patients.