Alternative to body surface area as a solution to correct systematic bias in pediatric echocardiography Z scores.

ABSTRACT Background: Z scores are the method of choice to report dimensions in pediatric echocardiography. Z scores based on body surface area (BSA) have been shown to cause systematic biases in overweight and obese children. Using aortic valve (AoV) diameters as a paradigm, the aims of this study were to assess the magnitude of Z score underestimation in children with increased body mass index Z score (BMI-Z) and to determine if a predicting model with height and weight as independent predictors would minimize this bias. Methods: In this multicenter, retrospective, cross-sectional study, 15,006 normal echocardiograms in healthy children 1-18 years old were analyzed. Residual associations with body size were assessed for previously published Z score. BSA-based and alternative prediction models based on height and weight were developed and validated in separate training and validation samples. Results: Existing BSA-based Z scores incompletely adjusted for weight, BSA and BMI-Z and led to an underestimation of >0.8 Z score units in subjects with higher BMI-Z, compared to lean subjects. BSA-based models led to overestimation of predicted AoV diameters with increasing weight or BMI-Z. Models using height and weight as independent predictors improved adjustment with body size, including in children with higher BMI-Z. Conclusions: BSA-based models result in underestimation of Z scores in patients with high BMI-Z. Prediction models using height and weight as independent predictors minimize residual associations with body size and generate well-fitted predicted values that could apply to all children, including those with low or high BMI-Z.