124: Outcomes of Novel Coronavirus Disease in Patients With Diabetes Mellitus: A Retrospective Analysis

INTRODUCTION: Coronavirus disease 2019 (COVID-19) is a multisystem infection caused by SARS-CoV-2 Virus Recent studies have demonstrated poor outcomes in patients with diabetes mellitus (DM) We sought to assess the in-hospital outcomes of COVID19 patients with DM at our centre METHODS: Ours was a single centre, retrospective, observational study of 470 COVID-19 patients admitted to our hospital We divided these patients into 2 groups;those with DM and those without We compared demographic characteristics, comorbid conditions, and in-hospital outcomes between the two groups Statistics were performed using STATA Statistical significance was assigned at p<0 05 RESULTS: Out of the 470 patients included in the study, 35 53% of patients had DM Mean age of patients with and without DM was 68 35years±1 08 vs 61 71±1 05years respectively 8 72% of patients were on pharmacological therapy The diabetic cohort had a higher prevalence of hypertension, heart failure compared to the non-diabetic cohort (88 02 vs49 5% p-value:0 004, 22 9% vs 9 31% p-value: 0 04) Other comorbidities such as OSA, CKD, COPD, Asthma were comparable between both groups The DM group had a higher level of inflammatory markers during the course of hospitalisation (D-dimer 3802 68± 1499 vs 3448 13 ±1139, CRP: 12 60±0 76 vs 11 85±0 60, ESR: 73 66±10 41 vs 58 04±7 10) The DM group had a significantly higher need for mechanical ventilation (18 56% vs 13 29%, p<0 03), and subsequent in-hospital mortality (43 35% vs 25 74% p<0 05) On multivariate regression, diabetics had 2 64 higher odds of in-hospital mortality, however, the p-value was not significant (Write ODDS Ratio and Confidence interval p-value: 0 116) CONCLUSIONS: Overall inpatient mortality was higher in patients with DM, likely driven by an increased need for mechanical ventilation Our study positively adds to the existing literature that DM is a significant risk factor for higher morbidity and mortality in COVID-19 patients