Effective Management of Allergy by a Siddha preparation- An In Vitro Study

Allergy or hypersensitivity is a common clinical condition encountered worldwide. Histamine and cytokines like interleukin (IL) 1α and IL8 play a key role in inflammatory allergic disorders. Mast cells and basophils release histamine on sensitization. Moreover, keratinocytes synthesize and release IL1α and IL8, which also activate basophils to release histamine. The present study demonstrates that G7, a Siddha medicine has properties in moderating the release of histamine, IL1α and IL8 and therefore is a promising alternative for the management of allergic disorders.