Photo-stimulated leaving group isomerization of acyl donor esters in protease-catalyzed hydrolysis reactions
2018
AbstractHydrolysis studies of photo-switchable N-maleyl-amino acid-(4-phenylazophenyl) esters of Ala, Gly, Met, Phe, and Pro were performed using the proteases trypsin and chymotrypsin. It has been found out that the cis-isomers were hydrolyzed faster than the trans-isomers. In dependence of the amino acid in the P1 position the velocity graduation is Phe > Met > Ala > Gly > Pro for trypsin and Phe ≫ Met > Ala > Gly > Pro for chymotrypsin for both isomers.
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