Impaired IL-10 Receptor Mediated Suppression in Monocyte from Patients with Crohnʼs Disease

ABSTRACTObjectives:Interleukin-10 (IL-10) is an immunoregulatory cytokine that has a central role in suppressing proinflammatory responses. Patients with deleterious mutations in interleukin (IL)-10 or IL-10 receptor (IL-10R) genes develop severe colitis and perianal disease in the first months of l