STUDY OF SERUM LIPID PROFILE AND LIPID RATIOS IN PATIENTS WITH RENAL FAILURE

Background: The burden of kidney disease is increasing rapidly worldwide and has become a major health issue. An association between lipid profile and renal failure has been recently reported in many studies in several countries. Aim: The current study was undertaken to examine the association of serum lipids, lipid ratios with Chronic Renal Failure in Jordan population. Methods: The study was carried out on 75 pre-dialysis chronic kidney disease patients attending out-patient clinic in Prince Zaid Military Hospital in Al-Tafilah in Jordan from February to October 2014 and 50 control subjects, all factors that may lead to dyslipidaemia were excluded in all subjects. Lipid profiles were measured by standard methods. Data were analyzed using a statistical software SPSS version 20.0, p-value <0.05 was considered significant. Results: Subjects with Chronic Renal Failure have significant higher total cholesterol concentrations compared with control group (214.32 ± 75.15 Vs. 177.41 ± 35.37 mg/dL, p< 0.05); also they have significant higher triglyceride concentrations (189.46 ± 68.53 Vs. 147.67 ± 94.35 mg/dL , p< 0.05). The mean ratio of total cholesterol/HDL-cholesterol was significantly higher in the Patients group than healthy subjects (4.53 ± 1.43 Vs. 3.81 ± 1.72, p< 0.05). LDL-cholesterol concentrations were lower in healthy groups (125.14 ± 63.39 Vs. 113.76 ± 35.63 mg/dL, p< 0.05). HDL-cholesterol concentrations were higher in healthy groups (54.14 ± 13.49 Vs. 43.16 ± 15.42 mg/dL, p< 0.05). The LDL-C/HDL-C ratios were higher in patients group (2.14 ± 1.49 Vs.1.16 ±0.92 mg/dL, p< 0.05). Conclusion: Abnormalities in lipids levels are common in pre-dialysis chronic kidney disease patients. It is valuable to investigate and treat dyslipidaemia early in the course of the disease as it may prevent further progression of the renal damage.