Mechanistic insight on the inhibition of D, D-carboxypeptidase from Mycobacterium tuberculosis by β-lactam antibiotics: an ONIOM acylation study.

Thandokuhle Ntombela,Anya Seupersad,Sibusiso B. Maseko,Collins U. Ibeji,Gideon F. Tolufashe,Siyabonga I. Maphumulo,Tricia Naicker,Sooraj Baijnath,Glenn E. M. Maguire,Thavendran Govender,Gyanu Lamichhane,Bahareh Honarparvar,Hendrik G. Kruger

Mechanistic insight on the inhibition of D, D-carboxypeptidase from Mycobacterium tuberculosis by β-lactam antibiotics: an ONIOM acylation study.

2021

Thandokuhle Ntombela
Anya Seupersad
Sibusiso B. Maseko
Collins U. Ibeji
Gideon F. Tolufashe
Siyabonga I. Maphumulo
Tricia Naicker
Sooraj Baijnath
Glenn E. M. Maguire
Thavendran Govender
Gyanu Lamichhane
Bahareh Honarparvar
Hendrik G. Kruger

Mycobacterium tuberculosis cell wall is intricate and impermeable to many agents. A D, D-carboxypeptidase (DacB1) is one of the enzymes involved in the biosynthesis of cell wall peptidoglycan and c...

Keywords:

Peptidoglycan
Acylation
ONIOM
Enzyme
Biochemistry
Mycobacterium tuberculosis
Lactam
Cell wall
Chemistry
Carboxypeptidase

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