Anaphylaxis to Cefazolin in the Second Trimester: A Case Report

Anaphylactic reactions during pregnancy are uncommon and can trigger maternal hypotension. These hemodynamic changes increase both maternal and fetal morbidity and mortality as emergent cesarean delivery is often necessary due to worsening fetal status. Only a handful of case reports describe perioperative and intraoperative management of anaphylaxis in pregnancy. We present a patient in her second trimester with twin-twin transfusion syndrome who experienced anaphylaxis to cefazolin prior to the start of a fetoscopic laser procedure for photocoagulation of pathological placental anastomoses.