Curcumin loaded deformable drug carrier for the disease of posterior segment of eye: Diabetic retinopathy

Diabetic Retinopathy (DR) is one of the most common complications of diabetes mellitus that affects theblood vessels of the retina, leading to blindness. The current approach of treatment based on anti-inflammatory, anti-angiogenesis drugs and laser photocoagulation are effective but also shows adverse affect in retinal tissues and that can even worsen the visual abilities. Thus, a safe and effective mode of treatment is needed to control or delaying the DR. Based on the earlier evidence of the potentiality of natural products as anti-oxidants, anti-diabetic and antitumor, medicinal plants may constitute a good therapeutic approach in the prevention of DR. Curcumin, constituents of dietary spice turmeric, has been observed to have therapeutic potential in the inhibition or slow down progression of DR. In this review, we summarize the therapeutic potentiality of curcumin in the delaying the DR through antioxidant, anti-inflammatory, inhibition of Vascular Endothelial Growth and nuclear transcription fac-tors. In period of time. Curcumin, the major extract of termuric, has been widely used in many countries for centuries both as a medicine. In the last decade, researchers have found the beneficial effects of curcumin on mutiple disorders are due to its antioxidant, anti-inflammatory, and antiproliferative properties, as well as its novel function as an inhibitor of histone aectyltransferases. In this review, we summarize the recent progress made on studying the benificial effect of curcumin on mutiple retinal diseases, including diabetic retinopathy, glaucoma, andage-releated macular degeneration. Recent clinical trials on the effectiveness of phosphatidylcholine formulated curcumin in treating eye diseases have also shown promising results, making curcumin a potent therapeutic drug candidate for inflammatory and degenerative retinal and eye diseases. Posterior segment dieases, including age-related macular degeneration (AMD), diabetic retinopathy, diabetic macular edema (DME), retinal vein occlusion (RVO), uveitis, and endophthalmitis, are responsible for causing visual impairment and blindness worldwide. The purpose of this study was to evaluate the therapeutic potential of opthalmic curcumin in the prevention and treatment of posterior segment of eye.