Deubiquitinase activity is required for the proteasomal degradation of misfolded cytosolic proteins upon heat-stress
2016
Ubiquitination of misfolded proteins usually results in protein degradation. Here, the authors show that two deubiquitinases—enzymes that remove ubiquitin—are required for the proteasomal degradation of misfolded proteins in response to heat-shock in yeast.
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