Comparison of serum levels of pyridinoline and pyridinoline cross-linked carboxy-terminal telopeptide of type I collagen as markers of bone resorption in patients receiving maintenance hemodialysis

Background Serum levels of pyridinoline, measured by high-performance liquid chromatography, and pyridinoline cross-linked carboxy-terminal telopeptide of type I collagen (ICTP), measured by a newly developed radioimmunoassay kit, were compared and analyzed to determine whether ICTP can replace pyridinoline as a marker of bone resorption in hemodialysis patients.