Efek Ekstrak Buah Pare (Momordica charantia Linn.) Terhadap Jumlah Sel Leydig Tikus Putih (Rattus norvegicus) Hiperglikemia

This research was conducted to evaluated the effects of bitter melon (Momordica charantia Linn.) extracts in the amount of Leydig cells hyperglycemic white rats (Rattus norvegicus). Twenty four white rats were randomly devided into six groups. Alloxan induced pancreatic damage was performed in five groups with 150 mg/kg body weight by intraperitoneal. Three groups was treatment with a dose therapy of bitter mellon extracts, (P1) 29mg/ml/day, (P2) 50 mg/ml/day, and (P3) 59 mg/ml/day, one group as a control negative was given CMC Na 0.5% 1ml/day, one group as a control positive was given Glibenclamide® 0.126 mg/ml/day. One group as a control normal was induced CMC Na 0.5% 1ml/day without alloxan 150 mg/kg body weight. After fourteen days treatment, twenty four white rats were killed and harvest the testes to made a histopathology preparations using Haematoxylin Eosin (HE) staining. The result showed that treatment with bitter melon (Momordica charantia Linn.) extracts 50 mg/ml/day dose increased the amount of Leydig cells (42.80 ± 4.55) of hyperglycemic white rats (p < 0.05).