1-(benzofuran-5-yl)-3-aryl-2-(triazol-1-yl)-propenone and application thereof as anticancer drug
2014
The invention relates to 1-(benzofuran-5-yl)-3-aryl-2-(1,2,4-triazol-1-yl)-2-propen-1-one or a salt thereof, and 1-(benzofuran-5-yl)-3-aryl-2-(1,2,4-triazol-1-yl)-2-propen-1-one or the salt thereof is represented by a chemical structure formula I or II. In the formula, R is selected from hydrogen, deuterium, C1-C2 alkyl, and C3-C4 alkyl; X1 and X5 are selected from hydrogen, deuterium, C1-C2 alkyl, C3-C4 alkyl, hydroxy, C1-C2 alkoxy, C3-C4 alkoxy, fluoro, chloro, bromo or nitro; X3 is selected from hydrogen, deuterium, C1-C2 alkyl, C3-C4 alkyl, hydroxy, C1-C2 alkoxy, C3-C4 alkoxy, fluoro, chloro, bromo or nitro; X2 and X4 are selected from hydrogen, deuterium, C1-C2 alkyl, C3-C4 alkyl or nitro. The invention also provides an application of 1-(benzofuran-5-yl)-3-aryl-2-(1,2,4-triazol-1-yl)-2-propen-1-one or the salt thereof in preparing anticancer drugs.
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