Zusammenhang zwischen flussassoziierter (endothelabhängiger) Vasodilatation und TSH-Spiegeln bei jungen, normotensiven und normoglykämischen Personen

Background: Endothelial dysfunction (ED) is regarded as an early step in the development of atherosclerosis. Recent experimental data showed a crosstalk between endothelial NO-synthase activity and thyrotropin production. Therfore we studied whether basal TSH can predict flow associated vasodilation (FAD) in a cohort of healthy young subjects with normal TSH levels. Patients and methods: FAD was evaluated in 60 normotensive and normoglycemic subjects (mean age 34 years; range 18–50). The mean thyroptropin level was 1.43 ± 0.11 muU/ml (range 0.18–3.52 muU/ml). Results: Comparing subjects in the upper, middle and lower tertile of TSH (2.38 ± 0.14 muU/ml, 1.23 ± 0.04 muU/ml and 0.65 ± 0.06 muU/ml respectively) there was no difference in terms of the classical cardiovascular risk factor profiles (24 h blood pressure, HDL- and LDL-cholesterol, triglycerides, oral glucose load and body fat content). Regarding the vascular parameters, we could neither find an independent association with FAD (7.0 ± 1.1%, 6.4 ± 1...