RASA1 and NF1 co-mutated non-small cell lung carcinomas: Cancer genomic data and evaluation of sensitivity to MEK inhibition.

Takuo Hayashi,Patrice Desmeules,Roger S. Smith,Alexander Drilon,Romel Somwar,Marc Ladanyi

RASA1 and NF1 co-mutated non-small cell lung carcinomas: Cancer genomic data and evaluation of sensitivity to MEK inhibition.

2017

Takuo Hayashi
Patrice Desmeules
Roger S. Smith
Alexander Drilon
Romel Somwar
Marc Ladanyi

11600Background: Ras-GTPase activating proteins (RasGAPs), notably NF1 and RASA1, mediate negative control of the RAS/MAPK pathway. While NF1 mutations are enriched in non-small cell lung carcinoma...

Keywords:

Cell
Cancer
Pathology
Lung
Cancer research
Medicine
negative control
MAPK/ERK pathway
non small cell
Carcinoma
genomic data

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