The Efficacy and safety of autologous bone marrow mononuclear cells transplantation by intracoronary infusion in patients with acute myocardial infarction

Objective To assess the efficacy and safety of autologous bone marrow mononuclear cells transplantation by intracoronary infusion in patients with AMI. Methods We studied 32 patients who underwent percutaneous coronary intervention (PCI) after AMI with NYHAⅡ- Ⅲ class. Thirty- two patients (21males and 11females) , who had AMI within previous four weeks, were divided into trial group and control group randomly. Normal saline or autologous bone marrow mononuclear cells (BM- MNCs) was infused into the infarct related artery (IRA) through the guiding catheter after PCI in control group and trial group respectively. ECG, Holter, SPECT were assessed before PCI , 45d, 90d after that. Results (1) BM- MNCs was cultured and harvested by the method of Ficoll. 1.6×108- 5.8×108 (3.5±1.8×108) BM- MNCs were obtained and more than 92% cells were alive.(2)SPECT scan.Results showed that perfusion defect decreased 34.32% and 23.05% than base- line at 45d in trial and control group respectively (P0.05).The perfusion defect decreased 14.77% and 3.82% at 90d than 45d in trial and control group respectively (P 0.05). (3)24 h electrocardiographic monitoring demonstrated that there was no difference in the occurrence of ventriarrhythmia or bradycardia before PCI, 45 and 90 d after that (P0.05).Conclusions BM- MNCs transplantation by intracoronary infusion have some efficacy in patients with AMI and malignant arrhythmias is not increased.