Hyperemia-Related Changes in Arterial Stiffness: Comparison between Pulse Wave Velocity and Stiffness Index in the Vascular Reactivity Assessment

Carotid-to-radial pulse wave velocity () has been proposed to evaluate endothelial function. However, the measurement of is not without limitations. A new simple approach could have wide application. Stiffness index (SI) is obtained by analysis of the peripheral pulse wave and gives reproducible information about stiffness of large arteries. This study assessed the effects of hyperemia on SI and compared it with in 14 healthy subjects. Both were measured at rest and during 8 minutes after ischemia. SI temporal course was determined. At 1 minute, SI and decreased ( to  m/s, ; to  m/s; , resp.). SI was positively related to in baseline ( , ), at 1 minute (, ), and during the whole experimental session (, ). Conclusion. Hyperemia significantly decreases SI in healthy subjects. SI was related to and could be used to facilitate the evaluation of hyperemia-related changes in arterial stiffness.