THE EFFECTS OF OOCYTE DONOR AND RECIPIENT BODY MASS INDEX ON LIVE BIRTH RATES AND PREGNANCY OUTCOMES FOLLOWING ASSISTED REPRODUCTION

Abstract. Objective To investigate the effects of oocyte donor and recipient BMI on outcomes of vitrified donor oocyte ART. Design Retrospective cohort study. Setting Private fertility center. Patient(s). 338 oocyte donors and 932 recipients who underwent 1651 embryo transfer cycles (2008-2015). Intervention(s) Multivariable log binomial regression models with cluster weighted generalized estimating equations were used to estimate the adjusted risk ratios (aRR). Main outcome measure(s) Live birth, defined as the delivery of at least one live born infant, including all embryo transfer cycles. Secondary outcomes included birth weight and gestational length only among singleton live births. Results The mean (standard deviation) BMI of donors and recipients was 22.6 kg/m2 (2.5 kg/m2) and 24.6 kg/m2 (4.8 kg/m2), respectively. There were no significant associations between donor BMI and probability of live birth. Recipients with a BMI≥35 kg/m2 had a significantly higher probability of live birth (aRR 1.30, 95% CI 1.11, 1.52) compared to normal weight recipients. Among singleton live births, recipients with a BMI Conclusions In the setting of vitrified donor oocyte ART, recipient BMI was positively associated with probability of live birth but negatively associated with gestational length and birthweight among singleton births.