Assessing effects of changing environment by a multiple pathway model of carcinogenesis
2000
To assess impacts of changing environment, in this paper we propose a multiple branching model of carcinogenesis and use the model to demonstrate how the changing environment would affect the incidence and the survival function of cancer tumors. It is shown through some computer simulation that if there are initiation and promotion on the two-stage pathway, then the effects of changing environment seem to be negligible.
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