Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference–based bone anabolic strategy

C. Liang,B Guo,H. Wu,N. Shao,D. Li,J. Liu,L. Dang,C. Wang,H Li,S Li,W.K. Lau,Yu Cao,Z. Yang,C. Lu,X. He,Doris W.T. Au,Xiaohua Pan,Bao-Ting Zhang,H. Zhang,Kevin K.M. Yue,A. Qian,P. Shang,Jiake Xu,L. Xiao,Z. Bian,W Tan,Zicai Liang,Fuchu He,Lingqiang Zhang,Aiping Lu,Ge Zhang

Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference–based bone anabolic strategy

2015

Osteoblast-specific aptamer-functionalized lipid nanoparticles could act as a new RNAi-based bone anabolic strategy, advancing the targeted delivery selectivity of osteogenic siRNAs from the tissue level to the cellular level.

Keywords:

Immunology
Anabolism
Aptamer
Small interfering RNA
RNA interference
Genetic enhancement
Medicine
Biochemistry
Molecular biology
Gene silencing
Virology
Cell biology
Nanoparticle
cellular level

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