FRI0181 Skin manifestations in secondary antiphospholipid syndrome – analysis of forthy patients

Background Skin lesions are common kind of connective tissue disease manifestations. Objectives The aim of study was evaluation of skin involvement in clinical presentation of 40 patients with systemic lupus erythematosus (SLE) and secondary antiphospholipid syndrome (APS). Methods Examined group (34 women and 6 men) was represented by patients who fullfiled diagnostic ARA criteria for both, SLE and APS. Average duration of disease was 7.54 ± 7.53 (1–33) years and average age of patients was 31.45 ± 13.95 (8–65) years. Patients with SLE without APS represented control group. Results We noticed cutaneous ulcerations in 15/40 (37.5%) patients from examined group. They were predominantly located at lower legs and fingers of palms. Cutaneous ulcerations were significantly more frequently (p = 0.025) appeared in patients with both, SLE and APS than in control group. Livedo reticularis was observed in 9/40 (22.5%) patients from examined group, the most frequently at lower legs but one patient expressed livedo reticularis at skin of the torso. There was no significant difference in comparison to control group where prevalence of livedo reticularis was 10% (2/20). We observed palmar-plantar erythema in 12.5% (5/40) patients with APS as a part of SLE. In control group, palmar-plantar erythema was noticed in 10% patients (2/20). Conclusion Our study demonstrated that cutaneous ulcerations occurs more frequently in patients with both, SLE and APS than in patients with SLE alone, probably because of two present pathogenic mechanisms: vasculitis and thromophillia as a part od APS. On the other hand, livedo reticularis and palmar-plantar erythema were presented with the same frequency in both groups of patients.