N4-hydroxycytosine dioxolane nucleosides and their activity against hepatitis B virus.

Jinfa Du,Laurent Hollecker,Junxing Shi,Byoung-Kwon Chun,Kyoichi A. Watanabe,Raymond F. Schinazi,Tammy Nachman,Stefania Lostia,Lieven Stuyver,Michael Otto

N4-hydroxycytosine dioxolane nucleosides and their activity against hepatitis B virus.

2005

Jinfa Du
Laurent Hollecker
Junxing Shi
Byoung-Kwon Chun
Kyoichi A. Watanabe
Raymond F. Schinazi
Tammy Nachman
Stefania Lostia
Lieven Stuyver
Michael Otto

Novel racemic, d- and l-β-dioxolane N 4-hydroxycytosine nucleosides have been synthesized and evaluated for their activity against hepatitis B virus. None of the synthesized nucleosides demonstrated selective anti-HBV activity.

Keywords:

Dioxolane
Nucleoside
Biochemistry
Virology
Hepatitis B virus
Chemistry

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