Effect of One Bout Submaximal Endurance Exercise on Blood Coagulation and Fibrinolytic Factors in Patients with Hypertension

Introduction: Hypertension is considered as a major risk factor for thrombotic events. The aim of this study was to investigate the effect of one bout submaximal endurance exercise on blood coagulation and fibrinolytic factors in patients with hypertension. Methods: 20 subjects were randomly selected out of 70 adult males with hypertension (Mean ± SD; age: 60.25±4.59 yr, body mass index (BMI): 29.57± 3.68 kg/m2, body fat percentage (BFP): 20.25± 5.31%, maximal oxygen uptake34.83±2.11ml/kg/min, systolic blood pressure(SBP): 147.20±6.43 mm Hg,diastolic blood pressure(DBP): 94.40±3.70 mm Hg). The participants carried out one bout submaximal endurance running for 30 minutes within 60 to 65% of maximal heart rate reserve (MHRR). Blood samples were immediately taken before and after exercise. Dependent variables were categorized into three groups including 1.Coagulation: fibrinogen (FIB), factor VIII (FVIII), prothrombin time (PT), prothrombin time activity (PTA), international normalized ratio (INR), activated partial thromboplastin time(aPTT), platelet (PLT), mean platelet volume (MPV) 2. Anticoagulation: protein C (PC), antithrombinIII (ATIII) 3. Fibrinolytic: d-dimer (D-D), tissue plasminogen activator (tPA), plasminogen activator inhibitor1 (PAI-I), tPA/PAI-1. For normalizing research data Shapiro- Wilk test was used. Data analysis was done by paired samples t-test at a significant level of (P≤0.05). Testing of the considered assumptions was carried out by SPSS software version 19. Results: Paired sample t-test showed a significant reduction in aPTT (P=0.001), tPA (P=0.001), tPA/PAI-1(P=0.014), PV (P=0.001) and a significant increase in FIB (P=0.001), FVIII (P=0.001), PLT (P==0.001), MPV (P=0.001), PC (P=0.001) and ATIII (P=0.001) levels. There was no significant change in PT (P=0.068), PTA (P=0.156), INR (P=0.060) and D-D (P=0.436)levels. Considering the volume of plasma, no significant changes in FIB were observed (P=0.814). Conclusion: It seems that submaximal endurance exercise activates the anticoagulation system which can overcome thrombotic conditions.