The Effectiveness of Lipofilm Microemulsion Eye Drops in Dry Eye Syndrome by Enhancing The Tear Film Quality

The aim of this study was to evaluate the effectiveness of lipofilm microemulsion as ocular lubricant in dry eye syndrome. It wasprospective randomized clinical trial design with single blind masked study. Sixty eyes were enrolled according to the inclusion andexclusion criteria. Two weeks and four weeks of follow-up were documented. Objective parameters were Schirmer I test and break uptime test. Subjective symptoms were assessed by means of 1-10 scale of visual analogic score. Thirty eyes were enrolled to lipofilmgroup and 30 eyes to sodium hyaluronate 0.15% group. Both groups had improvement in mean Schirmer test (p < 0.001) but therewas no statistically difference between two groups after two weeks (p = 0.361) and four weeks (p = 0.081). Both groups induced asignificant increase of break up time test (p < 0.001) and there was statistically significant difference in lipofilm group after two weeks(p = 0.037) and four weeks (p = 0.002). Symptoms improved in all groups but statistically significant different in lipofilm group inforeign body sensation (p = 0.001) and blurred vision (p = 0.021) after two weeks. Lipofilm tends to show a faster improvement thansodium hyaluronate in patients with dry eye syndrome