Overriding Ortho Selectivity by Template Assisted Meta-C–H Activation of Benzophenones

An orthogonal selectivity for distal meta-C–H activation of benzophenone is acheived by overriding the inherent proximal ortho-selectivity through template assisted metalation approach. This strategy has been successfully utilized in Pd-catalyzed regioselective C–C and C–Si bond formation.