Synthesis of Lapachone Derivates via Ionic Liquid-Mediated Tandem Knoevenagel/Diels-Alder Reaction

The use of ionic liquid (IL) in Tandem Knoevenagel/Diels-Alder Reaction is an optimization method for one-pot procedures, providing great results under mild conditions. In this paper, four new Lapachone derivatives were obtained using lawsone as substrate. The effects of the catalytic use of ionic liquids and catalysts in organometallic systems were evaluated. Several lapachone derivatives were obtained good to excellent yields.