The Effect of Implanting Sustained-release 5-Fluorouracil during Operation on Recurrence of Liver Cancer

Objective: To study the effect and adverse effect of implanting sustained-release 5-fluorouracil during hepatolobectomy to oppose metastasis of liver cancer.Method: 63 patients diagnosed with liver cancer were divided into two groups: group Ⅰ(n=32),ordinary chemotherapy group,patients with conventional chemotherapy after operation;group II(n=31),patients with sustained-release 5-fluorouracil during operation.Two groups were visited 1 year,observed the adverse effect,recurrence rate and death rate.Result: There's significant difference in liver function before operation(P0.05) of two groups.ALT,AST,TBL,PT,AFP in group II were much lower than group Ⅰ after operation(P0.05);The recurrence and transferring rate of group II was much lower than group I(P0.05);The incidence and mortality of group II were much lower than group Ⅰ(P0.05).Conclusion: The treatment of sustained-release 5-fluorouracil during hepatolobectomy can effectively reduce the rate of transferring,recurrence and death of liver cancer patients,increase the patients' compliance and tolerance,it may be a new therapy for patients with liver cancer after hepatectomy.