Determinants of recovery from amenorrhea in premenopausal breast cancer patients receiving adjuvant chemotherapy in the taxane era

631 Background: Chemotherapy (CT)-induced amenorrhea occurs in about 20–70% of premenopausal breast cancer (BC) patients (pts) and its incidence could depend on several factors. Iatrogenic amenorrhea can affect choice of hormone therapy (tamoxifen vs aromatase inhibitors), fertility, and quality of life of BC survivors. A benefit from the ovarian failure in hormone receptor positive BC pts is estimated since the estrogen production is suppressed. Methods: We retrospectively analyzed the incidence of amenorrhea after adjuvant CT and the subsequent recovery of the menses in 145 BC pts. Age, smoke, BMI, number of CT courses, CT regimen, number of childbearing were analyzed as potential predictive factors of ovarian function recovery. Results: Mean age was 43 years (range 23–58) at the beginning of adjuvant CT with a 30% of pts younger than 40 years. The mean value of BMI was 24.6 even though a 34% of pts presented with BMI>25. The majority (87.6%) of pts received an anthracycline-based CT, 35.2% of pts recei...