Evaluating the effect of probiotic supplementation in the form ofmouthwash along with scaling and root planingon periodontal indices in patients with generalized periodontitis stage III and grade A: A randomized clinical trial

Background: Periodontal disease is a chronic microbial infection. Non-surgical treatments, including scaling and root planing (SRP) with or without adjunctive treatmentsare among the recommended treatment options for this condition. The present study aimed to investigate the effect of probiotic supplementation in the form of mouthwash with SRP on periodontal indices in patients with generalized periodontitis stage III and grade A. Methods: 36 patients were randomly assigned to two groups (n=18) and received SRP treatment along with a placebo in one group and probiotic supplementation in the other. After SRP, the case group used daily probiotics for 20 days. The control group was treated only with SRP and placebo mouthwash. Periodontal indices were measured at three intervals: at baseline and after one and three months. The results were analyzed using SPSS 17. P<0.05 was considered statistically significant. Results: There were significant differences in BOP levels in both the case and control groups between different intervals. However, there was no significant difference between the groups. The significance of changes in the CAL and PI indices were similar to those in the BOP. There were significant differences in PD levels between the groups after one month and three months using the mouthwash. There were also significant differences between the PD values at different intervals in both groups. Conclusion: The present study showed that probiotic supplementation in the form of mouthwash, along with SRP, had a positive effect on periodontal indices in patients with generalized periodontitis stage III and grade A. IRCT registration number: IRCT20180630040290N2 Registration date: 2019-03-27, 1398/01/07