Facile Synthesis of N-1,2,4-Oxadiazole Substituted Sulfoximines from N-Cyano Sulfoximines

A divergent approach has been successfully developed for the synthesis of N- 1, 2, 4-oxadiazole substituted sulfoximines starting from N-cyano sulfoximines. This method has a wide degree of substrate scope that includes aryl, heteroaryl, alkyl, fluoroalkyl and saturated heterocyclic compounds. Excellent functional group tolerability was also observed. Extension of this methodology to nucleoside, amino acids and dipeptide was found to be successful. A gram scale reaction was also established. Major part of this method is metal free and utility of environmentally friendly solvents such as 2-methy THF and ionic liquids is an added advantage.