Traditional Chinese medicine refreshment intravenous injection nasal delivery preparation used for resuscitation and refreshment and preparation method of nasal delivery preparation

2012 
The invention relates to a traditional Chinese medicine refreshment intravenous injection nasal delivery preparation used for resuscitation and refreshment and a preparation method of the nasal delivery preparation, and belongs to the technical field of production of nasal delivery preparation. The preparation consists of a muscone extracting solution, natural borneol, geniposide extracts, radix curcumae curcumin extracts, radix curcumae essential oil, a cosolvent (namely, tween-80 or 1.2 propylene glycol), a promoting penetrating agent (namely, cyclodextrins), a preservative (namely, ethylparaben or potassium sorbate), and a solvent (namely, distilled water or water for injection). The preparation method comprises the following steps of: weighing the natural borneol, dissolving the natural borneol by using the cosolvent, adding the potassium sorbate or the ethylparaben to dissolve, filtering, adding the secondary distillate of musk into a filtrate, sequentially adding the radix curcumae essential oil and the promoting penetrating agent, stirring, adding the gardenia extracts and the radix curcumae curcumin extracts, stirring for 2 hours, filtering, adjusting PH to be 6.0-7.0 by using a phosphate buffer, and finally preparing the distillate or water for injection into 100ML of the preparation. According to the nasal delivery preparation, the potency of the active ingredients is improved greatly, and the volume is reduced, so that the nasal delivery preparation is suitable for nasal delivery.
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