MC-1R, MC-2R, and μ opioid receptor modulators

The present invention modulate the expression of the receptor of the POMC gene product (MC-1R, MC-2R, and μ opioid receptor), optionally also by adjusting the expression of POMC in skin cells, in particular, epidermal cells adjust the proliferation and differentiation, in order to re-epithelialization, in order to maintain the innervation, to recover to activate the skin, or a normal pigmentation, or for combating aging, or independently or to the active substance for modulating pigmentation regardless of skin aging. The present invention also relates to a method of screening for such actives. .BACKGROUND