Late Stage Lead Diversification (LSLD) Coupled with Quantitative NMR Spectroscopy to Identify New SAR Vectors at Nanomole Scale Synthesis: Application to Loratadine a Human Histamine H1 Receptor Inverse Agonist.

Manjinder S. Lall,Asser Bassyouni,James Bradow,Maria S. Brown,Mark W. Bundesmann,Jinshan Chen,Gregory Ciszewski,Anne E. Hagen,Dennis Hyek,Stephen Jenkinson,Bo Liu,R. Scott Obach,Senliang Pan,Usa Reilly,Neal W. Sach,Daniel Smaltz,Douglas K. Spracklin,Jeremy T. Starr,Melissa Wagenaar,Gregory S. Walker

Late Stage Lead Diversification (LSLD) Coupled with Quantitative NMR Spectroscopy to Identify New SAR Vectors at Nanomole Scale Synthesis: Application to Loratadine a Human Histamine H1 Receptor Inverse Agonist.

2020

An experimental approach is described for late stage lead diversification (LSLD) of frontrunner drug candidates using nanomole scale amounts of lead compounds for SAR development. The process utili...

Keywords:

Spectroscopy
Histamine H1 receptor
Inverse agonist
Chemistry
late stage
Biochemistry
Loratadine
quantitative nmr

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